MP64-04 mpMRI FOR STAGING OF PROSTATE CANCER: A MULTICENTRIC ANALYSIS OF PREDICTIVE FACTORS TO IMPROVE IDENTIFICATION OF EXTRACAPSULAR EXTENSION BEFORE RADICAL PROSTATECTOMY

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VI (MP64)1 Sep 2021MP64-04 mpMRI FOR STAGING OF PROSTATE CANCER: A MULTICENTRIC ANALYSIS PREDICTIVE FACTORS TO IMPROVE IDENTIFICATION EXTRACAPSULAR EXTENSION BEFORE RADICAL PROSTATECTOMY Lucas Regis, Marina Triquell, Mathias Winkler, Adrià Piñero, Cintia López-Molina, Nicolás Valdés, Mercè Cuadras, Ana Celma, Jacques Planas, Juan Morote, and Enrique Trilla RegisLucas Regis More articles by this author , TriquellMarina Triquell WinklerMathias Winkler PiñeroAdrià Piñero López-MolinaCintia López-Molina ValdésNicolás Valdés CuadrasMercè Cuadras CelmaAna Celma PlanasJacques Planas MoroteJuan Morote TrillaEnrique View All Author Informationhttps://doi.org/10.1097/JU.0000000000002104.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Staging for high-risk prostate cancer (PCa) is important in the surgical planning radical prostatectomy (RP). The correct identification extracapsular extension (ECE) on crucial order plan nerve-sparring approach. aim study was asses negative predictive value detecting ECE before RP; identifying possible operative variables that predict final prostatic specimen. METHODS: We retrospectively investigate data base two tertiary high-volume hospitals identify men who underwent biopsy with pre-biopsy subsequent RP. Positive MRI detect pT3a disease assessed. Univariate multivariate analysis were performed. RESULTS: Of a total 1263 RP, 1147 patients met our inclusion criteria. mean PSA 9.23 37.4% had positive DRE. stage iT3+ found 248 (21.6%); 203 (17.7%) iT3a. showed staging statistically correlated pathological staging, p<0.01. specimen 42%. ability exclude greater 73%. performed including PSA, density (PSAd), % core affected, ISUP, PSAd DRE only independent predictors Analyzing ROC curve (AUC 0.66), ≥ 0.20ng/dL/mL best threshold pT3a. CONCLUSIONS: seems be an appropriate tool thereby facilitating nerve-sparing Patients MRI, normal <0.20 ng/dL/mL are unlikely may suitable extrafascial nerve-sparig strategies. Additional radiomic improve detection further. Source Funding: None © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1111-e1111 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...